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Image Search Results
Journal: Journal of Inflammation Research
Article Title: Regulation of the Immune Microenvironment by an NLRP3 Inhibitor Contributes to Attenuation of Acute Right Ventricular Failure in Rats with Pulmonary Arterial Hypertension
doi: 10.2147/JIR.S336964
Figure Lengend Snippet: Flow Cytometry Antibody
Article Snippet: CD45 , 561586 ,
Techniques: Flow Cytometry, Marker
Journal: Journal of Inflammation Research
Article Title: Regulation of the Immune Microenvironment by an NLRP3 Inhibitor Contributes to Attenuation of Acute Right Ventricular Failure in Rats with Pulmonary Arterial Hypertension
doi: 10.2147/JIR.S336964
Figure Lengend Snippet: Changes in the proportion of immune cells in myocardial tissue were analysed via flow cytometry. ( A ) The proportion of CD45 + cells in each group was detected by flow cytometry. ( B ) The proportion of CD45 + CD11b + cells in each group was detected by flow cytometry. ( C ) The proportion of CD68 + CD86 + cells in each group was detected by flow cytometry. ( D ) Pulmonary hypertension and LPS caused a significant increase in the proportion of CD45-positive inflammatory cells in right ventricular tissue (normal vs PAH, normal vs normal + LPS, n = 3). ( E ) CD45-positive/CD11b-positive mononuclear macrophage infiltration was significantly elevated in right ventricular tissues from rats subjected to PAH or LPS (normal vs PAH, normal vs normal + LPS, normal + LPS vs PAH + LPS, n = 3). ( F ) The proportion of CD68-positive/CD86-positive M1 macrophages was decreased in the hearts of PAH rats and significantly increased in the right ventricular tissues of PAH rats stimulated with LPS, but MCC950 application significantly inhibited the change in the proportion of CD68-positive/CD86-positive M1 macrophages (n = 3). The significance of the difference was analysed by one-way ANOVA, **p < 0.01, ***p < 0.001, ****p < 0.0001.
Article Snippet: CD45 , 561586 ,
Techniques: Flow Cytometry